Search results for "International literature"
showing 10 items of 12 documents
A Simple Method to Predict Blood-Brain Barrier Permeability of Drug- Like Compounds Using Classification Trees
2017
Background: To know the ability of a compound to penetrate the blood-brain barrier (BBB) is a challenging task; despite the numerous efforts realized to predict/measure BBB passage, they still have several drawbacks. Methods: The prediction of the permeability through the BBB is carried out using classification trees. A large data set of 497 compounds (recently published) is selected to develop the tree model. Results: The best model shows an accuracy higher than 87.6% for training set; the model was also validated using 10-fold cross-validation procedure and through a test set achieving accuracy values of 86.1% and 87.9%, correspondingly. We give a brief explanation, in structural terms, o…
Israeli Spotted Fever in Sicily. Description of two cases and minireview
2017
Mediterranean spotted fever (MSF) is endemic in Italy, where Rickettsia conorii subsp. conorii was thought to be the only pathogenic rickettsia and Rhipicephalus sanguineus the vector and main reservoir. R. conorii subsp. israelensis, which belongs to the R. conorii complex, is the agent of Israeli spotted fever (ISF); apart from Israel, it has also been found in Italy (Sicily and Sardinia) and in different regions of Portugal. We describe here two severe cases of ISF which occurred in otherwise healthy Italian adults. Their characteristics are analyzed and discussed in the light of other 91 cases found through a systematic review of international literature.
Psychotropic Drugs in the Management of Chronic Pain Syndromes
1993
Psychotropic drugs have been integrated into the management of chronic pain syndromes for more than 30 years. Numerous open and controlled studies have taken place evaluating especially the antinociceptive efficacy of antidepressive drugs. This survey comprises the results of clinical reports, open clinical studies, placebo-controlled studies, and comparative studies of different substances. It will be shown that antidepressants are by far the best evaluated psychopharmacological substances, showing superiority against placebo in 70% of a total of 67 placebo-controlled studies. The synopsis of controlled comparison studies of different antidepressants tends to demonstrate a superiority of c…
More on the Dimensionality of the GHQ-12: Competitive Confirmatory Models
2019
The General Health Questionnaire (GHQ) was designed to measure minor psychiatric morbidity by assessing normal ‘healthy’ functioning and the appearance of new, distressing symptoms. Among its versions, the 12-item is one of the most used. GHQ-12’s validity and reliability have been extensively tested in samples from different populations. In the Spanish version, studies have come to different conclusions, of one, two, and three-factor structures. This research aims to present additional evidence on the factorial validity of the Spanish version of the GHQ-12, using competitive confirmatory models. Three samples of workers (N= 525, 414 and 540) were used to test a set of substantive models pr…
Photochemical genotoxicity: principles and test methods
2004
In recent years, assessing the photogenotoxic potential of a compound became an issue for certain drugs and cosmetical products. Therefore, existing methods performed according to international guidelines (e.g. OECD guidelines) were adapted to the use of concurrent UV-visible (UV-Vis) light irradiation for the assessment of photomutagenicity/photogenotoxicity. In this review, photobiological bases of the processes occurring in the cell after irradiation with UV- and/or visible (vis)-light as well as a compilation of testing methods is presented. Methods comprise cell free investigations on naked DNA and in vitro methods, such as the photo-Ames test, the photo-HPRT/photo-mouse lymphoma assay…
Actinomadura pelletieri mycetoma--an atypical case with spine and abdominal wall involvement.
2011
We describe a case of mycetoma caused by Actinomadura pelletieri with simultaneous involvement of the spine, abdominal wall and retroperitoneal space in a man who had suffered from ‘Madura foot’ 10 years earlier. The characteristics of this case were analysed and contextualized among those of other cases of mycetoma caused by other micro-organisms found through a review of the international literature. The rarity of the disease in industrialized countries and its possible atypical presentations may hinder a prompt diagnosis. Culture techniques that allow detection of slow-growing fungi and actinomycetes should be routinely used when dealing with tissue samples from patients from tropical an…
Publications on paediatric anaesthesia: a quantitative analysis of publication activity and international recognition.
2000
A comprehensive compilation of the current international literature on paediatric anaesthesia is lacking. The aim of this study was to identify all articles on clinical practice in paediatric anaesthesia, to name the respective journals, and to assess the publication activity and international recognition of selected countries for a 6-yr period (1993–1998). The search comprised an article-to-article evaluation (‘hand search') of 12 peer-reviewed anaesthesia journals, as well as an Internet-based (‘SilverPlatter') MedlineTM-search (3.900 medical journals, US National Library of Medicine), both limited to original articles, case reports, reviews and editorials. Selected physical characteristi…
The topics of international publications on paediatric anaesthesia from 1993 to 1998.
2000
A comprehensive compilation of the current international literature on paediatric anaesthesia is still lacking. It was the aim of this study to identify all publications with a focus on paediatric anaesthesia, and to determine the spectrum of topics, as well as the publication type and language for the period between 1993 and 1998. All articles published in 12 major anaesthesia journals were evaluated and, additionally, a computerized, Internet-based Medline-search was performed using selected keywords. The analysis was limited to original articles, case reports, reviews and editorials. For the period between 1993 and 1998, a total of 2259 (377 per year) publications on paediatric anaesthes…
The ecosocial approach in social work as a framework for structural social work
2016
The article aims to deepen the understanding of structural social work from the point of view of the ecosocial framework. It analyses selected current international literature from the debate on the new wave of various interpretations of ecological social work. The debate shares four main themes: (a) a global perspective, (b) a critical view of professional social work, (c) a holistic ecosocial transition of society and (d) environmental and ecological justice. The ecosocial framework challenges structural social work to follow the principles of sustainable development and considers environmental issues as a crucial part of the goals and practical activities of structural social work.
El rol del asociacionismo de inmigrantes africanos en la construcción de cohesión social y la convivencia en Cataluña, Navarra y la Comunidad Valenci…
2013
This article aims to analyse some possible contributions from organisations funded by immigrants from the African continent to the socio-cultural integration in three Regions in Spain. In order to do so, first there is a definition of integrations as a process, paying special attention to the role that national and international literature have given to the associations of immigrants. Afterwards, there is a focus on associations from people with an African origin, paying attention to the double view point, from one side the one from representatives from African associations and on the other, from administration technicians and representatives of social entities that collaborate with them. T…